The Karuso Lab
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Peter Karuso
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2D NMR Spectrum
Peter Karuso

Peter Karuso

Peter Karuso


@ University of Sydney

@ University of Sydney

Cert. Higher Ed. @ Macquarie University

Outstanding Teacher
Award 2000
@ Macquarie University

Fellowship of Royal
Australian Chemical
Institute 2000


Dr. Karuso is Professor of Organic Chemistry in the Department of Chemistry A& Biomolecular Sciences, Macquarie University. He obtained his Ph.D. in Organic Chemistry from the University of Sydney. This was followed by several post-doctoral appointments: Department of Zoology, University of Auckland; Department of Chemistry, University of Hawaii; Department of Biochemistry and Biophysics, Texas A&M University; Department of Organic Chemistry at the Technische Universitaet Muenchen as an Alexander von Humbolt Fellow before returning to Australia to take up an appointment as Lecturer in Biotechnology and Organic Chemistry at Macquarie University. The has served as head of Department (2002-2005) and as the Chief Scientific Officer of the University start-up company, Fluortechnics (2003-2008)

Prof. Karuso's interests span the full spectrum of natural products chemistry, with particular emphasis on chemical biology, marine natural products chemistry and bioorganic chemistry. The latter includes the synthesis and study of potential enzyme inhibitors. A common theme of much of this research is the conformational analysis of biomolecules in solution using modern NMR techniques in combination with molecular modelling/dynamics. Prof. Karuso also manages the NMR facility and the Macquarie node of VisLab.

Research Interests

  • Bioorganic and natural product chemistry
  • Marine natural products
  • Bioactive compounds from Australian insects and African medicinal plants
  • Phage display in the isolation of natural product receptors
  • Rational design and synthesis of enzyme inhibitors and DNA-binding metal complexes
  • Structure of biomolecules by NMR spectroscopy
  • Biodegradation of chlorinated pollutants

Current Collaborations

  • Xavier Franck, CNRS, University Rouen - Synthesis of epicocconone and analogs
  • Anindya Datta, IIT(Bombay) - Characterisation of natural fluorophores