Protein Structure Group - Department of Chemistry & Biomolecular Sciences
We have developed a structural genomics program based on microbial gene cassettes isolated directly from environmental and cultivated bacteria. This allows us to scope the amazing genetic and functional diversity resident within the bacterial mobile metagenome, without restriction to any specific gene family. Due to the highly unusual sequences of mobile genes, solving the structures of the encoded proteins is often the only way of finding out their specific function. Using a high throughput structural pipeline we aim to determine the structures of integron-derived proteins in order to discover new types of protein folds, as well as to reveal their role in the molecular evolution of adaptation.
Robinson A, Guilfoyle AP, Sureshan V, Howell M, Harrop SJ, Boucher Y, Stokes HW, Curmi PM, Mabbutt BC. Structural genomics of the bacterial mobile metagenome: an overview. Methods Mol Biol. 2008;426:589-95. PMID: 18542892